Undoubtedly South Africa's best safari destination!
If it's the Big 5 you're looking for in quite an extensive area, you can't go wrong with a Kruger National Park (KNP). You can not cover the whole park in a day - or two, or three - so I usually plan a tour spanning at least 5 days. If you're on a self-drive, firstly by a map. Take care - some of the older maps only cover the park up to Letaba - the older size of the KNP. Any of the Kiosks in the park sells a complete map in book format which also contains additional information for each specific area, as well as a summary of birds and mammals with pictures included. Also, if you can - buy a Wildcard. If you stay for a few days then it will cost you less than the conservation fees to be paid when entering the park. And entry to the park will be free.
I usually enter the park at the southern Malelane gate and sleep over in a different camp every night, exiting the park at one of the most northern gates (eg. Pafuri) on my last day. That gives me the opportunity to cover all of its habitat ( bushveld in the south, mopani bushes upper middle and raw bushveld north) and animal variety (from my experience rhinos and raptors occur mostly in the southern half of the park and smaller bird varieties in the north-most parts).
Lower Sabie is a good choice to start off your tour but avoid the tent-chalets in case you run into bad weather and and 'adventure' ends up in a sleepless, worrysome night! Lower Sabie has a beautiful restaurant with river view. Skakuza is also a well established camp - just make sure that utensils are supplied as some of the booking options don't. Satara is also well established and my favourite camp in the park. All your needs are catered for in the chalets and it also has a nice restaurant if you do not want to self-cater. The roads around Satara cover my favourite routes - make sure you get onto the S36 just north of Skukuza on your way to Satara. It's a reasonably long drive along a dirt road so pack a picnic basket and enough drinks for the day and start your trip as early as possible (6:00am at the latest). When at Satara, ensure that you drive along the S100 closeby - early morning as well as at dusk. It always has a surprise in store as far as lions / leopards are concerned! I suggest staying over at Satara for more than one night due to the abundance of wildlife in its vicinity and ample roads to go and look for them.
Take the S40 further north and keep your eyes open for the big cats. Stop for a rest at the Timbavati picnic spot and be aware that similar to the other official picnic spots in the park, you're proveded with free gass barbeques here if you have the ingredients for breakfast with you. And you don't even have to clean it yourself after use!
Sleep over more than one night at Elephants Camp. It has a great restaurant if you don't want to self-cater and the view is the most beautiful in the KNP - overlooking the Olifants River from a hillside. Raptors patrol the hillside in abundance from early to late so if you want to photograph Yellow-billed Kites, vultures and other eagles then this is the place to be. The bats enter the scene in droves at sunset and the kites actually wait for that moment, catching a snack just before bedtime!
I have not slept over at Letaba yet but it's one of my favourite stops for brunch / lunch at their restaurant overlooking the Letaba River. I have not slept over at Mopani yet but I usually drive through to Shingwedzi. This has a few nice dirt roads to be discovered in the area. Travel the S52 a bit to the south to Red Rocks. It has another official picnic spot close by with a nice river view and again - free cooking facilities.
The last sleeping spot is Punda Maria. But be aware - you have only community cooking facilities here and a little less privacy as all units are in 'barack' format. In other words, your room is adjacent to two other rooms on your sides. The roads in the vicinity do not disappoint yet again and be on the lookout for the big 5.
Pafuri is the northern most and one of my favourite areas in the KNP. Ever wished you could travel roads reminding you of the old Tarzan movies? This is the place! Unfortunately the Pafuri camp had not been restored (yet in 2015) after heavy floods in 2013 so if you want to sleep over in this area (which I highly recommend!) then book into the Pafuri River Camp 4km outside of the park and drive into the park early in the morning (and thank me for recommending the wildcard!). Drive along the S63 as early as possible and be prepared for something you'll never see again in your life! Up to about 8h30 thousands (I'm not kidding!) of crocodiles lay on the river banks waiting for heat from the rising sun. Just as many hippos show themselves and move along the shifting tree shades until it gets too hot, after which the croc's and hippo's disappear below the water surface and you'll never guess that the river is infested with them!
In general I'm not too fond of official day drives but do it once or twice just to say you've done it. The field guides provide great information about anything around you and who knows - you might just bump into a big cat feast or even witness a kill. Do a night drive as well as you'll see some nocturnal animals.